Measurement of serum digitalis glycosides: clinical implications.
نویسنده
چکیده
منابع مشابه
شناسایی گلیکوزیدهای قلبی گونه دیژیتال ایران به روش HPLC
Background and Purpose: Digitalis species and their cardiac glycosides are used in congestive heart failure (ÇHF) disease. Digitalis nervosa are grown only in the North regions of Ïran. Çardiac glycosides of other species are identified by HPLÇ procedure. Ïn this research, cardiac glycosides of Digitalis nervosa were identified. Materials and Methods: Ïn this research, methanol as solvent ...
متن کاملPharmacokinetics, bioavailability and serum levels of cardiac glycosides.
Digoxin, the cardiac glycoside most frequently used in clinical practice in the United States, can be given orally or intravenously and has an excretory half-life of 36 to 48 hours in patients with serum creatinine and blood urea nitrogen values in the normal range. Since the drug is excreted predominantly by the kidney, the half-life is prolonged progressively with diminishing renal function, ...
متن کاملBidirectional Tachycardia after an Acute Intravenous Administration of Digitalis for a Suicidal Gesture
Acute digoxin intoxication is a life-threating condition associated with severe cardiotoxicity. Female gender, age, low lean body mass, hypertension, and renal insufficiency may worsen the prognosis. Arrhythmias caused by digitalis glycosides are characterized by an increased automaticity coupled with concomitant conduction delay. Bidirectional tachycardia is pathognomonic of digoxin intoxicati...
متن کاملInterruption of the enterohepatic circulation of digitoxin by cholestyramine. II. Effect on metabolic disposition of tritium-labeled digitoxin and cardiac systolic intervals in man.
Previous studies of digitalis glycoside metabolism and excretion have indicated that these compounds undergo a significant enterohepatic cycle in some species. It has been suggested that the existence of such a cycle in man contributes to the prolonged action of certain cardiac glycosides. Previous studies have demonstrated that cholestyramine binds digitoxin and digoxin in vitro and accelerate...
متن کاملStudies on tritum-labeled digoxin: tissue, blood and urine determinations.
During the last 40 years extensive investigations have been reported on various aspects of the metabolism of cardiac glycosides. A detailed review describing the cellular basis of cardiac glycoside action has been reported by Hajdu and Leonard (1). One prime difficulty encountered in determining the metabolic fate of cardiac glycosides is in establishing a reliable and sensitive method for dete...
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ورودعنوان ژورنال:
- Circulation
دوره 43 2 شماره
صفحات -
تاریخ انتشار 1971